健康な加齢のための循環器による全身への影響(簡潔な考察)

 How can we elongate our lifetime over 120? In the simple model, if we regenerate our cell/tissue/organ, we may enable this. However, we need to change “almost whole body”, because all cells in all body region have timer/watch. For example, could we change bone? Aging is systemic. This “systemic” provides us hint. Typical systemic body histrology is “blood vessel”. Blood vessel could affect all regions, resulting affect Aging alike. M. Grunewald et al. show that age-related vascular endothelial growth factor (VEGF) affect life span in mice(1). Exercise benefits in cardiovascular diseases(2). Therefore, suitable degree of daily exercise may be important for healthy aging. The histology(solid system) including endothelial tissue and tight junction and fluid system including immune system of vascular system may be important. Immune landscape may partly affect lifespan(3). Keeping vascular system healthy may be fundamental for extension of life span.
 
(Reference)
(1)
M. Grunewald1,*, S. Kumar1,†, H. Sharife1,†, E. Volinsky1,†, A. Gileles-Hillel1,2,3, T. Licht1, A. Permyakova4, L. Hinden4, S. Azar4, Y. Friedmann5, P. Kupetz1, R. Tzuberi1, A. Anisimov6, K. Alitalo6, M. Horwitz1, S. Leebhoff1, O. Z. Khoma7, R. Hlushchuk7, V. Djonov7, R. Abramovitch2, J. Tam4, E. Keshet1,*
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
Science  30 Jul 2021:Vol. 373, Issue 6554, eabc8479
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Author affiliation
1Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
2Wohl Institute for Translational Medicine and the Goldyne Savad Institute for Gene Therapy, Hadassah Hospital, Jerusalem, Israel.
3Pediatric Pulmonology and Sleep Unit, Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
4Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
5Bio-Imaging Unit, The Alexander Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
6Translational Cancer Biology Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
7Topographic and Clinical Anatomy, Institute of Anatomy, University of Bern, Bern, Switzerland.
† These authors contributed equally to this work
(2)
Carmen Fiuza-Luces, Alejandro Santos-Lozano, Michael Joyner, Pedro Carrera-Bastos, Oscar Picazo, José L. Zugaza, Mikel Izquierdo, Luis M. Ruilope & Alejandro Lucia
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Nature Reviews Cardiology volume 15, pages731–743 (2018)
(3)
KosuKosuke Hashimoto, Tsukasa Kouno, Tomokatsu Ikawa, Norihito Hayatsu, Yurina Miyajima, Haruka Yabukami, Tommy Terooatea, Takashi Sasaki, Takahiro Suzuki, Matthew Valentine, Giovanni Pascarella, Yasushi Okazaki, Harukazu Suzuki, Jay W. Shin, Aki Minoda, Ichiro Taniuchi, Hideyuki Okano, Yasumichi Arai, Nobuyoshi Hirose, Piero Carninci,
"Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians",
Proceedings of the National Academy of Sciences (PNAS),