//Question//---
Do you think that SARS-CoV-2 vaccination
for children must proceed in the world? What is the critical age?
//Fact//---
*Most children has low to moderate symptom
in SARS-CoV-2 infection(1,2), but a very limited portion of young patients has
multisystem inflammatory syndrome(MIS-C)(3).
*Children play a minimal role in spreading
the infection to others(4). Therefore, epidemiological risk is small.
*Vaccination safe protocol is ethically
difficult(4), but now the clinical trial for the children (12-15 years old)
proceeds(5,6).
*Ongoing physical distance in the school
life leads to problematic psychological and physical negative consequences(7).
//My opinion//---
*Only one time dose, not booster dose can
be considered as vaccination trials after confirmation of safety like mRNA
vaccine.
*On the neonates, antibody transport via
breastfeeding needs to be investigated.
*Vaccine (physiology, safety) that has
already been approved could be referred for the SARS-CoV-2 vaccine program for
the young children.
(Reference)
(1)
Andrea D. Praticò & Martino Ruggieri
COVID-19 vaccination for children: may be
necessary for the full eradication of the disease
Pediatric Research (2021)
---
Author information
Affiliations
Unit of Rare Diseases of the Nervous System
in Childhood, Department of Clinical and Experimental Medicine, University of
Catania, Catania, Italy
Andrea D. Praticò & Martino Ruggieri
(2)
Mehta, N. S. et al.
SARS-CoV-2 (COVID-19): What do we know
about children? A systematic review.
Clin. Infect. Dis. 71, 2469 – 79 (2020).
(3)
Radia, T. et al.
Multi-system in flammatory syndrome in
children & adolescents (MIS-C): a systematic review of clinical features
and presentation.
Paediatr. Respir. Rev. S1526-0542, 30117 –
2 (2020).
(4)
Opel, D. J., Diekema, D. S. & Ross, L.
F.
Should we mandate a COVID-19 vaccine for
children?
JAMA Pediatr. 175, 125 – 6 (2021).
(5)
Wallace, M. et al.
The Advisory Committee on Immunization
Practices ’ Interim Recommendation for Use of P fi
zer-BioNTech COVID-19 Vaccine in Adolescents Aged 12-15 Years - United States,
May 2021.
MMWR 70, 749 – 52 (2021).
(6)
Tanne, J. H.
Covid-19: FDA authorises P fi zer vaccine for children 12-15.
BMJ 11, 1204 (2021).
(7)
Praticò, A. D.
COVID-19 pandemic for pediatric health care:
disadvantages and opportunities.
Pediatr. Res. 89, 709 – 10 (2021).
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